Indigenous knowledge plays a vital role in sustaining ecosystems, strengthening community resilience, and preserving cultural identity, yet it has long been marginalized by dominant global systems. Revitalizing and protecting this knowledge helps address modern challenges such as climate change, public health needs, equitable development, and more by drawing on place-based experience accumulated across generations. Integrating traditional practices with scientific methods and emerging technologies can create more sustainable, community-driven solutions while safeguarding cultural heritage. Efforts to validate and preserve indigenous knowledge systems (IKS) also challenge colonial legacies and promote greater respect for diverse worldviews, ultimately contributing to social justice and inclusive innovation. Revitalizing Indigenous Knowledge Systems in the 21st Century reclaims and recognizes the value of IKS in the 21st century by examining their significance, promoting their restoration, and highlighting their integration with contemporary issues and disciplines. It further fosters recognition and integration of IKS in various sectors, such as health, education, sustainable development, and environmental conservation. Covering topics such as community-affixed curricula, knowledge autonomy, and urban heritage protection, this book is an excellent resource for academicians, postgraduate students, policymakers, practitioners, cultural institutions, and more.