Two cousins: Emily, a young American witch & Erika, an Indian lycan meet a vampiress from England. Emily and Erika come of age in early America during the late 1700s in the pre-state of Tennessee. Emily's uncle, to the chagrin of her father, Robert, visits Chickasaw Indian land and marries, producing Em's cousin, Erika. Over their formative years, Emily is kept from seeing her uncle Jed (for Robert knows nothing of his daughter); as his prejudices are strong against the natives, and now, his own brother. Nonetheless, the girls become aware of each other through 'dream-walking' abilities they both seem to possess. Erika by way of her Indian beliefs; Emily by blood, as her mother is a retired witch, also unknown by Robert. Simultaneously, during this period, an English woman-turned-vampire seeks refuge in the land of opportunity to escape a downward-spiraling situation of her own making - revenge murders upon those responsible for sending her on mission where she was ultimately turned into a vampire-cannibal hybrid. Eventually, the three ladies lives wind up on collision course to rendezvous, resulting in a wildly dark and dangerous adventure.