As we move deeper into the 21st century, globalisation continues to transform the spaces around international borders, and the social processes, cultural practices, economies, and political dynamics within and between these spaces. Drawing from examples on the US-Mexico border (with comparisons to Europe), this book examines how border regions have become important places in their own right, areas where people live, work, create art; where companies invest, crimes occur, and security is a concern. They are spaces that need to be better understood and managed, especially given the cross-national and global forces acting upon them. This book was published as a special issue of Global Society.