It is widely accepted that innovation holds the key to sustainable commercial growth globally, but in practice there is limited understanding of how to successfully exploit its full commercial and social value. The Scale-up Manual provides a unified approach to manage the creation and commercialisation of innovative products and services, enabled by four data-driven building blocks: the Triple Chasm Model, modified Commercialisation Readiness Levels, meso-economic Vectors and the Commercialisation Canvas. The approach supports different strategies for resource allocation, ranging from 'lean' techniques to sustainability initiatives based on the circular economy. The Manual includes many case studies and insights, which different 'Actors' can use at different points along the commercialisation journey.