Novel Approaches into the Origins of Neurodevelopmental Disorders: The Fetal Physiology Foundation Over the past two decades, autism, a neurodevelopmental disorder that is defined by behavior and was once believed to be rare, became recognized in increasing numbers of children and recently received distinction as an "epidemic" [1]. While numbers of affected children have steadily increased, our knowledge is still ins- ficient to explain autism's diverse causes and broad range of presentations. Despite remarkable progress in research, available medical diagnostic testing applies only to a small minority of affected children. Thus, scientifically based explanations with which physicians can diagnose and treat the majority of children with autism and advise their parents are quite limited. Our society and scientific community were unprepared for the rise in autism, which explains our present inability to understand most of its causes. Researchers in neurodevelopmental disorders have long been aware of other disorders that, despite extensive efforts, have not yielded clear genetic or environmental origins, and autism has become symbolic of the need for new approaches to research into these complex conditions. Although autism has captured our attention in recent years, the prevalence of other neurodevelopmental disorders such as attention de- cit hyperactivity disorder (ADHD) and bipolar disorder, among others, also has been increasing [2-4].
The study of maternal influences on the intrauterine environment as they relate to the developing fetal brain promises to be an important area of study. Findings in this area may make it possible to delineate the prenatal mechanisms that affect ongoing cell programming in the fetus and lead to neurodevelopmental disorders. Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects advances the field by discussing a wide range of issues impacting several neurodevelopmental disorders. These include ADHD, autism, schizophrenia, bipolar disorder and obsessive-compulsive disorder. Of value to practitioners and researchers in the areas of pediatric neurology, obstetrics and gynecology, fetal physiology, neuroscience, genetics, developmental medicine, perinatology, toxicology and developmental psychology, Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects joins together research from various disciplines and demonstrates interrelated and common themes that can direct current and future multidisciplinary research and clinical care.
From the reviews:
"This interesting book examines an extremely pertinent topic in obstetrics, the gene-environment interplay and its effects on the developing human brain. ? Clearly the authors have done a good job of reviewing relevant literature as well as provoking new ideas. ? The audience includes clinicians and scientists interested in the fetal origin of disease. ? this is an interesting book about a worthwhile topic in obstetrics. ? it is a worthwhile contribution to the field." (Anthony Shanks, Doody's Review Service, December, 2010)
