Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry,
Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants-such as antibiotics, steroids, analgesics-using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.
The most advanced techniques for analyzing unknown and emerging contaminants
n recent years, we have witnessed an increase in mass accuracy from greater than 5 ppm to less than 1 ppm. At the same time, resolving power for benchtop time-of-flight mass instruments has increased from 2,000–5,000 to 10,000–20,000. Responding to these and other important new developments in mass spectrometry, this contributed work reviews, synthesizes, and analyzes the latest discoveries, techniques, and practical applications in accurate mass analysis. The authors are all leading experts, many of whom are pioneers in the development of time-of-flight techniques to address environmental problems.
Liquid Chromatography Time-of-Flight Mass Spectrometry is divided into three parts:
-
Part One: Principles and Theoretical Aspects of Accurate Mass, sets forth the fundamentals of accurate mass by liquid chromatography/time-of-flight (LC/TOF) mass spectrometry
-
Part Two: Tools for Unknown Identification Using Accurate Mass, explores the gamut of TOF tools, including exact-mass databases, isotopic mass defects, and isotopic ratios and neutral losses
-
Part Three: Applications of LC/TOF-MS for the Identification of Small Molecules, examines applications across a broad range of disciplines, including pharmaceuticals, pesticides, veterinary medicine, toxicology, forensics, environmental science, and food analysis
Throughout the book, theoretical discussions are illustrated with concrete examples that show readers how to perform their own accurate analyses.
By arming chemists with the principles, tools, and applications of LC/TOF mass spectrometry, this book enables them to apply the most advanced techniques to analyze unknown and emerging contaminants with the greatest level of accuracy possible.
